cwot: Cauchy Weighted Joint Test for Pharmacogenetics Analysis
A flexible and robust joint test of the single nucleotide polymorphism (SNP) main effect and genotype-by-treatment interaction effect for continuous and binary endpoints. Two analytic procedures, Cauchy weighted joint test (CWOT) and adaptively weighted joint test (AWOT), are proposed to accurately calculate the joint test p-value. The proposed methods are evaluated through extensive simulations under various scenarios. The results show that the proposed AWOT and CWOT control type I error well and outperform existing methods in detecting the most interesting signal patterns in pharmacogenetics (PGx) association studies. For reference, see Hong Zhang, Devan Mehrotra and Judong Shen (2022) <doi:10.13140/RG.2.2.28323.53280>.
Version: |
0.1.0 |
Imports: |
stats, SPAtest, mvtnorm |
Published: |
2022-09-23 |
Author: |
Hong Zhang [aut,
cre] |
Maintainer: |
Hong Zhang <hzhang at wpi.edu> |
License: |
GPL-2 |
NeedsCompilation: |
no |
CRAN checks: |
cwot results |
Documentation:
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