crispRdesignR: Guide Sequence Design for CRISPR/Cas9

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the 'R' console with sgRNA_Design() or through 'crispRdesignR's' user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

Version: 1.1.6
Depends: R (≥ 2.10)
Imports: Biostrings, gbm, GenomicRanges, BiocGenerics, IRanges, GenomeInfoDb, S4Vectors, rtracklayer, stringr, vtreat, shiny, DT
Suggests: BSgenome.Scerevisiae.UCSC.sacCer2
Published: 2021-01-11
Author: Dylan Beeber [aut, cre], Frederic Chain [aut]
Maintainer: Dylan Beeber <dylan.beeber at gmail.com>
License: GPL-3
URL: <https://github.com/dylanbeeber/crispRdesignR>
NeedsCompilation: no
Materials: README
CRAN checks: crispRdesignR results

Downloads:

Reference manual: crispRdesignR.pdf
Package source: crispRdesignR_1.1.6.tar.gz
Windows binaries: r-devel: crispRdesignR_1.1.6.zip, r-release: crispRdesignR_1.1.6.zip, r-oldrel: crispRdesignR_1.1.6.zip
macOS binaries: r-release (arm64): crispRdesignR_1.1.6.tgz, r-release (x86_64): crispRdesignR_1.1.6.tgz, r-oldrel: crispRdesignR_1.1.6.tgz
Old sources: crispRdesignR archive

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