Changes in version 2.0.0 - Added support for directed cell-cell interaction (see calculate_gene_scores_directed, calculate_influence) - Functions for supporting ligand-receptor interactions based on directed cell-cell interactions - Added ligand–receptor and gene-set scoring utilities: calculate_lr_scores, calculate_gene_set_score, and calculate_gene_set_specificity. - Added support for handling Visium HD - plotting functions using circlize for showing ligand-receiver interactions. - API and naming standardization (backwards-incompatible) Major public functions renamed to snake_case for consistency (examples: calcInfluence → calculate_influence, getInteractingGenes → get_interacting_genes, getPairwiseInteractingGenes → get_pairwise_interacting_genes, getSpatialFeatures → get_spatial_features, getSpatialParameters → get_spatial_parameters) Changes in version 1.5.0 - Added findAllHotspots to use with getPairwiseInteractingGenes - Return empty interacting genes list instead of failing with error when no genes pass fdr threshold. Changes in version 1.2.0 - Updated SpaceMarkersMetric by fixing signage and log transformed to scale magnitude - Added get_spatial_paramsExternal which enables getting spatial parameters from file or from the user. - Deprecated getSpatialParameters - Enabled includeSelf = TRUE in getInteractingGenes.R to improve hotspot detection - Enabled load10XCoords to read coordinates from VisiumHD directory - Optimized the long running row.dunn.test() function - Corrected sparse -> dense conversions - Added getPairwiseInteractingGenes which enables pairwise analysis of interacting patterns - getSpatialFeatures: add default method to infer the object passed to it. Changes in version 0.1.0 - Added a NEWS.md file to track changes to the package.