phase1PRMD: Personalized Repeated Measurement Design for Phase I Clinical Trials

Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Version: 1.0.2
Depends: R (≥ 3.0.0), coda (≥ 0.13), ggplot2, stats
Imports: rjags, arrayhelpers, MASS, reshape2, plyr, dplyr, RColorBrewer, gridExtra, kableExtra, knitr
Published: 2020-03-09
DOI: 10.32614/CRAN.package.phase1PRMD
Author: Lu Zhang, Jun Yin
Maintainer: Lu Zhang <luzhangstat at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
SystemRequirements: JAGS (
Materials: README NEWS
CRAN checks: phase1PRMD results


Reference manual: phase1PRMD.pdf


Package source: phase1PRMD_1.0.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): phase1PRMD_1.0.2.tgz, r-oldrel (arm64): phase1PRMD_1.0.2.tgz, r-release (x86_64): phase1PRMD_1.0.2.tgz, r-oldrel (x86_64): phase1PRMD_1.0.2.tgz
Old sources: phase1PRMD archive


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