Package: AlphaMissenseR
Title: Accessing AlphaMissense Data Resources in R
Version: 1.4.0
Authors@R: 
    c(person(
        "Martin", "Morgan", role = c("aut", "cre"),
        email = "mtmorgan.xyz@gmail.com",
        comment = c(ORCID = "0000-0002-5874-8148")
    ), person(
        "Tram", "Nguyen",
        role = "aut",
        comment = c(ORCID = "0000-0003-4809-6227")
    ), person(
        "Tyrone", "Lee",
        role = "ctb"
    ), person(
        "Nitesh", "Turaga",
        role = "ctb"
    ), person(
        "Chan Zuckerberg Initiative DAF CZF2019-002443",
        role = "fnd"
    ), person(
        "NIH NCI ITCR U24CA180996",
        role = "fnd"
    ), person(
        "NIH NCI IOTN U24CA232979",
        role = "fnd"
    ), person(
        "NIH NCI ARTNet U24CA274159",
        role = "fnd"
    ))
Description: 
    The AlphaMissense publication
    <https://www.science.org/doi/epdf/10.1126/science.adg7492>
    outlines how a variant of AlphaFold / DeepMind was used to predict
    missense variant pathogenicity. Supporting data on Zenodo
    <https://zenodo.org/record/10813168> include, for instance, 71M
    variants across hg19 and hg38 genome builds. The 'AlphaMissenseR'
    package allows ready access to the data, downloading individual
    files to DuckDB databases for exploration and integration into *R*
    and *Bioconductor* workflows.
License: Artistic-2.0
URL: https://mtmorgan.github.io/AlphaMissenseR/
BugReports: https://github.com/mtmorgan/AlphaMissenseR/issues
Depends: R (>= 4.3.0), dplyr
Imports: rjsoncons (>= 1.0.1), DBI, duckdb (>= 0.9.1), rlang, curl,
        BiocFileCache, spdl, memoise, BiocBaseUtils, utils, stats,
        tools, methods, whisker, ggplot2
Suggests: BiocManager, BiocGenerics, GenomicRanges, GenomeInfoDb,
        AnnotationHub, ExperimentHub, ensembldb, httr, tidyr, r3dmol,
        bio3d, shiny, shiny.gosling, ggdist, gghalves, colorspace,
        knitr, rmarkdown, testthat (>= 3.0.0)
biocViews: SNP, Annotation, FunctionalGenomics, StructuralPrediction,
        Transcriptomics, VariantAnnotation, GenePrediction,
        ImmunoOncology
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.2
VignetteBuilder: knitr
Config/testthat/edition: 3
git_url: https://git.bioconductor.org/packages/AlphaMissenseR
git_branch: RELEASE_3_21
git_last_commit: bef8604
git_last_commit_date: 2025-04-15
Repository: Bioconductor 3.21
Date/Publication: 2025-04-15
NeedsCompilation: no
Packaged: 2025-04-15 21:19:46 UTC; biocbuild
Author: Martin Morgan [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-5874-8148>),
  Tram Nguyen [aut] (ORCID: <https://orcid.org/0000-0003-4809-6227>),
  Tyrone Lee [ctb],
  Nitesh Turaga [ctb],
  Chan Zuckerberg Initiative DAF CZF2019-002443 [fnd],
  NIH NCI ITCR U24CA180996 [fnd],
  NIH NCI IOTN U24CA232979 [fnd],
  NIH NCI ARTNet U24CA274159 [fnd]
Maintainer: Martin Morgan <mtmorgan.xyz@gmail.com>
