SPIA

Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Author	Adi Laurentiu Tarca , Purvesh Kathri and Sorin Draghici
Maintainer	Adi Laurentiu Tarca

To install this package, start R and enter:

    source("http://bioconductor.org/biocLite.R")
    biocLite("SPIA")

Documentation

SPIA	PDF	R Script
Reference Manual

Details

biocViews	Microarray , GraphsAndNetworks
Depends	R , graphics , RCurl
Imports	graphics , RCurl
Suggests	graph , Rgraphviz , KEGGgraph
System Requirements
License	GPL (>=2)
URL	http://bioinformatics.oxfordjournals.org/cgi/reprint/btn577v1
Depends On Me
Imports Me
Suggests Me	KEGGgraph
Development History	Bioconductor Changelog

Package Downloads

Package source	SPIA_1.0.0.tar.gz
Windows binary	SPIA_1.0.0.zip
MacOS X 10.4 (Tiger) binary	SPIA_1.0.0.tgz
MacOS X 10.5 (Leopard) binary	SPIA_1.0.0.tgz
Package Downloads Report	Downloads Stats