Version 1.4.0 ------------- FEATURES: o Add convenience functions for creating and reading multiple SNV profiles o Add functionality for reading general COSMIC mutational data, not just cell line mutational data FIXES: o Fix an issue when reading COSMIC data due to new GRanges functionality MISCELLANEOUS: o Update the citation info with the now-published seqCAT-specific article VERSION 1.2.0 ------------- FEATURES: o Add functionality for analysing VCF files containing unannotated variants o Add functionality for listing non-overlapping variants between profiles o Mitochondrial variants can now be optionally skipped when reading SNV profiles in the `read_variants` function o Add the `list_variants` function for listing the genotypes of user-specified variants in each provided SNV profile o Add the `plot_variant_list` function for plotting a genotype grid for each variant output by the `list_variants` function FIXES: o Fix a multi-sample VCF profile creation issue (python only) o Reading zero-variant profiles now properly returns a GRanges object with a dummy-variant profile containing the sample name o Enable the `plot_impacts` function to properly analyse multi-impact SNVs o Fix reading of SNV profiles containing single-quoted strings VERSION 1.0.0 ------------- FEATURES: o Create single nucleotide variant (SNV) profiles from RNA/DNA-seq samples o Characterise the biological equivalency and difference between samples o Evaluate putative impacts of SNVs differing between samples o Investigate and validate known variants and specific genomic regions o Authenticate cell lines with a known SNV profile or the COSMIC database