SCATE

This package is for version 3.12 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see SCATEData.

SCATE: Single-cell ATAC-seq Signal Extraction and Enhancement


Bioconductor version: 3.12

SCATE is a software tool for extracting and enhancing the sparse and discrete Single-cell ATAC-seq Signal. Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) is the state-of-the-art technology for analyzing genome-wide regulatory landscapes in single cells. Single-cell ATAC-seq data are sparse and noisy, and analyzing such data is challenging. Existing computational methods cannot accurately reconstruct activities of individual cis-regulatory elements (CREs) in individual cells or rare cell subpopulations. SCATE was developed to adaptively integrate information from co-activated CREs, similar cells, and publicly available regulome data and substantially increase the accuracy for estimating activities of individual CREs. We demonstrate that SCATE can be used to better reconstruct the regulatory landscape of a heterogeneous sample.

Author: Zhicheng Ji [aut], Weiqiang Zhou [aut], Wenpin Hou [cre, aut] , Hongkai Ji [aut]

Maintainer: Wenpin Hou <wp.hou3 at gmail.com>

Citation (from within R, enter citation("SCATE")):

Installation

To install this package, start R (version "4.0") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("SCATE")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("SCATE")
1. SCATE package HTML R Script
Reference Manual PDF
NEWS Text
LICENSE Text

Details

biocViews ExperimentData, ExperimentHub, Genome, SNPData, SequencingData, SingleCellData, Software
Version 1.0.0
In Bioconductor since BioC 3.12 (R-4.0) (3.5 years)
License MIT + file LICENSE
Depends parallel, preprocessCore, splines, splines2, xgboost, SCATEData, Rtsne, mclust
Imports utils, stats, GenomicAlignments, GenomicRanges
System Requirements
URL
Bug Reports https://github.com/Winnie09/SCATE/issues
See More
Suggests rmarkdown, ggplot2, knitr
Linking To
Enhances
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package SCATE_1.0.0.tar.gz
Windows Binary SCATE_1.0.0.zip
macOS 10.13 (High Sierra) SCATE_1.0.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/SCATE
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/SCATE
Bioc Package Browser https://code.bioconductor.org/browse/SCATE/
Package Short Url https://bioconductor.org/packages/SCATE/
Package Downloads Report Download Stats
Old Source Packages for BioC 3.12 Source Archive