MetNet

This package is for version 3.10 of Bioconductor; for the stable, up-to-date release version, see MetNet.

Inferring metabolic networks from untargeted high-resolution mass spectrometry data


Bioconductor version: 3.10

MetNet contains functionality to infer metabolic network topologies from quantitative data and high-resolution mass/charge information. Using statistical models (including correlation, mutual information, regression and Bayes statistics) and quantitative data (intensity values of features) adjacency matrices are inferred that can be combined to a consensus matrix. Mass differences calculated between mass/charge values of features will be matched against a data frame of supplied mass/charge differences referring to transformations of enzymatic activities. In a third step, the two matrices are combined to form a adjacency matrix inferred from both quantitative and structure information.

Author: Thomas Naake [aut, cre]

Maintainer: Thomas Naake <thomasnaake at googlemail.com>

Citation (from within R, enter citation("MetNet")):

Installation

To install this package, start R (version "3.6") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("MetNet")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("MetNet")
Workflow for high-resolution metabolomics data HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews ImmunoOncology, MassSpectrometry, Metabolomics, Network, Regression, Software
Version 1.4.2
In Bioconductor since BioC 3.8 (R-3.5) (5.5 years)
License GPL-2
Depends R (>= 3.5)
Imports bnlearn (>= 4.3), BiocParallel(>= 1.12.0), GENIE3(>= 1.7.0), methods (>= 3.5), mpmi (>= 0.42), parmigene (>= 1.0.2), ppcor (>= 1.1), sna (>= 2.4), stabs (>= 0.6), stats (>= 3.6)
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Suggests BiocGenerics(>= 0.24.0), BiocStyle(>= 2.6.1), glmnet (>= 2.0-18), igraph (>= 1.1.2), knitr (>= 1.11), rmarkdown (>= 1.15), testthat (>= 2.2.1)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package MetNet_1.4.2.tar.gz
Windows Binary MetNet_1.4.2.zip
Mac OS X 10.11 (El Capitan) MetNet_1.4.2.tgz
Source Repository git clone https://git.bioconductor.org/packages/MetNet
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/MetNet
Bioc Package Browser https://code.bioconductor.org/browse/MetNet/
Package Short Url https://bioconductor.org/packages/MetNet/
Package Downloads Report Download Stats
Old Source Packages for BioC 3.10 Source Archive